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- Open Access
Quantification of the myocardial partition coefficient for intravenous iron (ferric carboxymaltose) using T1 mapping cardiovascular magnetic resonance
© Abdula et al. 2016
- Published: 27 January 2016
- Cardiovascular Magnetic Resonance
- Iron Overload
- Intravenous Iron
- Cardiovascular Magnetic Resonance Imaging
- Ferric Carboxymaltose
Cardiovascular magnetic resonance (CMR) T1 mapping has recently been shown to be highly sensitive for detecting myocardial iron overload. Furthermore, T1-mapping can be used to quantify relative concentrations of contrast agents that shorten T1. We hypothesized that T1 mapping can detect and quantify the myocardial distribution of a clinically available intravenous iron substitution agent.
CMR imaging was performed in healthy male volunteers (n = 8, mean ± SD age 27 ± 3 years). T1 of blood and myocardium was quantified using a modified Look-Locker inversion recovery (MOLLI) sequence for T1-mapping in a mid-ventricular short-axis slice at 1.5T (Siemens Aera). Images were acquired before and at regular intervals up to 50 minutes after onset of a 15 minute long injection of 20 ml (50 mg iron/ml) ferric carboxymaltose (Vifor Pharma). T1, R1 and ΔR1 of myocardium and blood, and the partition coefficient (lambda) for myocardium were measured over time.
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