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Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

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Two-center clinical validation of free breathing respiratory triggered retrospectively cardiac gated steady-state free precession (RT-SSFP) cine imaging in adults


Notwithstanding all the advantages of the cine bSSFP there are certain limitations, especially in sedated patients, patients with impaired breath-holding capacity, and those with cardiac arrhythmias. Any respiratory motion due to unsteady breath-hold during data acquisition causes motion artifacts, sacrificing endocardial border definition. In this study we clinically validate a RT-SSFP sequence for free breathing acquisition of cardiac cine images.


All imaging for this prospective, IRB approved study, was performed on 1.5T/3T commercial MR scanners (Achieva/Ingenia, Philips Healthcare) at two independent institutes (IA,IB). A real-time adaptive RT-SSFP sequence synchronizing the drive to SS with respiratory cycle along with retrospective cardiac gating was implemented[1]. The performance of RT-SSFP was validated prospectively against breath-hold (BH-SSFP) acquisition with identical acquisition parameters (TR/TE/flip angle = 2.5-2.7 ms/1.25-1.35 ms/ 70°; acqd voxel size = 1.7-2.0 × 1.6-2.0 × 8 mm3; SENSE factor = 1.3-1.9; temp res 40-50 ms; imaging time : 6-8 RR intervals/slice) for LV function evaluation in 22(IA,50(19-82)yrs) and 21(IB,47(23-86)yrs) consecutive patients undergoing clinically indicated cardiac MR. The image quality was scored by blinded reviewer for blood to myocardial contrast, endocardial edge definition, and motion artifacts (Table 1). Bland-Altman analysis was performed on clinical scores assigned to both the techniques.

Table 1 Clinical Score criteria


The RT-SSFP sequence ran successfully in all 43 patients. Total image acquisition time for RT-SSFP (5.9 ± 1.5 min) was significantly longer than conventional BH-SSFP (3.4 ± 1.0 min) (p < 0.001). Combined clinical score was Excellent (80%) to Good (20%) for BH-SSFP and Excellent (38%)-Good (40%)-Moderate (22%) for RT-SSFP (Fig.1). Only in one patient edge definition and motion artifact were scored as Poor.


While image quality scores were slightly lower for RT-SSFP compared to BH-SSFP, RT-SSFP images were consistently rated as diagnostic quality or better. Previous studies have shown that there was no statistically significant difference in the quantitative metrics of global LV function estimated using RT and BH techniques [1, 2]. We note that a vast majority of subjects in this study were good breathholders (BA plot), and RT-SSFP images were of equivalent image quality. Inclusion of more difficult clinical cases in comparison study may reveal the added value of free breathing cine SSFP alternative. The free breathing RT-SSFP sequence generates diagnostic cine MR images with contrast and spatio-temporal resolutions that are comparable to BH SSFP sequence at the expense of modest sacrifice in image quality in patients able to perform reasonable breath hold. Global LV functional parameters obtained from the two sequences were in good agreement. Thus, FB RT sequence may be a robust alternative for evaluating global LV function in patients with impaired breath-holding capacity.

Figure 1
figure 1

Bar plot (A) and Bland-Altman plot (B) for clinical scores. Bar plots depict percentage of patients receiving Excellent, Good, Moderate, Poor clinical scores for specific criterions for blood to myocardial contrast (BMC), endocardial edge definition (Edef), and artifacts (Art). The combined score is the equal weights average of the three scores. Results of the Bland-Altman analyses of clinical score, given by the clinical expert, reveals the change in clinical score for each patient. Horizontal axis of Bland-Altman plot is the clinical score for BH-SSFP and vertical axis is the BH minus RT score. Blue stars correspond to patients from Institute A and orange diamonds those from Institute B.


  1. JCMR. 2015, 17: 1-

  2. JCMR. 2014, 16 (Suppl 1): P30-

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Pednekar, A., Cheong, B., Wang, H. et al. Two-center clinical validation of free breathing respiratory triggered retrospectively cardiac gated steady-state free precession (RT-SSFP) cine imaging in adults. J Cardiovasc Magn Reson 18 (Suppl 1), P263 (2016).

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