- Poster presentation
- Open Access
High-Resolution MR Characterization of Myocardial Infarction using Compressed Sensing with Edge Preservation
© Zhang et al. 2016
- Published: 27 January 2016
- Infarct Region
- Isotropic Resolution
- Total Variation Regularization4
- Edge Preservation
- Spatiotemporal Signal
Characterization of infarct heterogeneity can inform therapeutic strategies for ventricular tachycardia and the management of patients with prior myocardial infarction (MI)1,2. Multi-contrast late-enhancement (MCLE)3 images along the signal-relaxation curve, acquired in a breath-hold ECG-gated scan, offer better visualization of MI than conventional IR-FGRE. However, current MR images either with IR-FGRE or MCLE provide an inferior spatial resolution of 1.6-2.0 mm in-plane with a slice thickness of 5-8 mm in the clinical setting, which is not sufficient to properly delineate infarct heterogeneity. This work presents a three-dimensional MCLE sequence accelerated using variable density Poisson-disk sampling and also proposes a novel reconstruction method using Compressed Sensing with Edge Preservation (COSEP), achieving an in-vivo isotropic resolution of 1.5 mm within a single breath-hold.
Three Yorkshire pigs with six-week-old infarcts were imaged after injection of Gadolinium-DTPA of 0.2 mmol/kg using 3D MCLE with a 160 × 160 × 10 acquisition matrix over a 1.5 cm-thick slab with corresponding resolution of 1.5 mm3. The undersampled datasets were prospectively acquired using Variable density Poisson-disk sampling patterns at a net acceleration of 5 with a 16-channel anterior cardiac coil array in a GE 3T scanner. The temporal signal-relaxation characteristic vectors were extracted from a training set, generated with a pre-defined model, using principal component analysis and then utilized to recursively transform spatiotemporal signal vectors to spatial principal component (PC) maps during the reconstruction. Local weighted total variation regularization4 was then applied to the CS framework to preserve anatomical edges in the infarct regions on the reconstructed spatial PC coefficient maps. For comparison, an alternative reconstruction method REPCOM5 was implemented and the IR-FGRE images were also acquired with the parameters as follows: matrix = 160 × 160, FOV = 24 cm and slice thickness = 5 mm.
We successfully demonstrated that high-resolution characterization of myocardial infarction in vivo is feasible using accelerated 3D MCLE with the COSEP reconstruction. We have shown that an isotropic resolution of 1.5 mm was achieved within single breath-hold in an in-vivo prospective pig study.
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