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Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

  • Poster presentation
  • Open Access

Extracellular volume fraction mapping at 3T with non-rigid image co-registration

  • 1,
  • 1, 2,
  • 3,
  • 1,
  • 1,
  • 1, 4,
  • 1, 5,
  • 1 and
  • 2
Journal of Cardiovascular Magnetic Resonance201618 (Suppl 1) :P32

  • Published:


  • Cardiovascular Magnetic Resonance
  • Hypertrophic Cardiomyopathy
  • Motion Correction
  • Diffuse Fibrosis
  • Chronic Myocardial Infarction


MOLLI-based T1-mapping is a robust method for myocardial tissue characterization. Extracellular volume fraction (ECV), a marker of diffuse fibrosis, requires pre- and post-contrast T1 values. However, ECV mapping is not widely available because of complexities in motion correction and image co-registration. Here, we demonstrated ECV mapping using a novel approach for motion compensation at 3T.


All patients underwent cardiovascular magnetic resonance (CMR) on a 3T system (Philips Ingenia). T1 maps were acquired in the basal and mid-cavity short-axis level, pre- and 20-min post-contrast (Gadovist 0.1 mmol/kg) with a 5s(3s)3s and 4s(1s)3s(1s)2s MOLLI acquisition scheme, respectively. A modified non-rigid, non-parametric registration method consisting of elastic registration steps was applied to generate motion-corrected T1 maps and subsequent ECV maps [1]. T1 error maps and overlay images were used as an indication for quality control. Global ECV values were expressed as mean+/-standard deviation (SD).


A total of 33 ECV maps were obtained in 18 patients (mean age 47+/-19 years, 12 males): 10 with chronic myocardial infarction and 8 with dilated and hypertrophic cardiomyopathies. 28 cases (85%) demonstrated clear improvement in image quality after motion correction and co-registration. Two examples are shown in Figures 1 and 2. Global ECV values in the patients with myocardial infarction and cardiomyopathies were 34.9+/-4.9% and 36.4+/-6.0%, respectively.
Figure 1
Figure 1

Native myocardial T1 map without (left) and with (right) motion correction at 3T. Arrows indicate motion misalignment that was corrected by the proposed approach.

Figure 2
Figure 2

Myocardial extracellular volume fraction (ECV) map without (left) and with (right) co-registration. Arrows indicate motion misalignment that was corrected by the proposed approach.


Automated motion correction and co-registration improved the quality of T1 and ECV maps at 3T, making ECV mapping feasible for clinical application.

Authors’ Affiliations

National Heart Centre, Singapore, Singapore
Philips Healthcare, Singapore, Singapore
Philips Research, Hamburg, Germany
University College London, London, UK
Imperial College London, London, UK


  1. Kabus : WBIR. 2010Google Scholar


© Le et al. 2016

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.