- Poster presentation
- Open Access
Extracellular volume fraction mapping at 3T with non-rigid image co-registration
Journal of Cardiovascular Magnetic Resonance volume 18, Article number: P32 (2016)
MOLLI-based T1-mapping is a robust method for myocardial tissue characterization. Extracellular volume fraction (ECV), a marker of diffuse fibrosis, requires pre- and post-contrast T1 values. However, ECV mapping is not widely available because of complexities in motion correction and image co-registration. Here, we demonstrated ECV mapping using a novel approach for motion compensation at 3T.
All patients underwent cardiovascular magnetic resonance (CMR) on a 3T system (Philips Ingenia). T1 maps were acquired in the basal and mid-cavity short-axis level, pre- and 20-min post-contrast (Gadovist 0.1 mmol/kg) with a 5s(3s)3s and 4s(1s)3s(1s)2s MOLLI acquisition scheme, respectively. A modified non-rigid, non-parametric registration method consisting of elastic registration steps was applied to generate motion-corrected T1 maps and subsequent ECV maps . T1 error maps and overlay images were used as an indication for quality control. Global ECV values were expressed as mean+/-standard deviation (SD).
A total of 33 ECV maps were obtained in 18 patients (mean age 47+/-19 years, 12 males): 10 with chronic myocardial infarction and 8 with dilated and hypertrophic cardiomyopathies. 28 cases (85%) demonstrated clear improvement in image quality after motion correction and co-registration. Two examples are shown in Figures 1 and 2. Global ECV values in the patients with myocardial infarction and cardiomyopathies were 34.9+/-4.9% and 36.4+/-6.0%, respectively.
Automated motion correction and co-registration improved the quality of T1 and ECV maps at 3T, making ECV mapping feasible for clinical application.
Kabus : WBIR. 2010
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Le, T.T., Zhang, S., Kabus, S. et al. Extracellular volume fraction mapping at 3T with non-rigid image co-registration. J Cardiovasc Magn Reson 18 (Suppl 1), P32 (2016). https://doi.org/10.1186/1532-429X-18-S1-P32
- Cardiovascular Magnetic Resonance
- Hypertrophic Cardiomyopathy
- Motion Correction
- Diffuse Fibrosis
- Chronic Myocardial Infarction