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- Open Access
Extracellular volume fraction mapping at 3T with non-rigid image co-registration
© Le et al. 2016
- Published: 27 January 2016
- Cardiovascular Magnetic Resonance
- Hypertrophic Cardiomyopathy
- Motion Correction
- Diffuse Fibrosis
- Chronic Myocardial Infarction
MOLLI-based T1-mapping is a robust method for myocardial tissue characterization. Extracellular volume fraction (ECV), a marker of diffuse fibrosis, requires pre- and post-contrast T1 values. However, ECV mapping is not widely available because of complexities in motion correction and image co-registration. Here, we demonstrated ECV mapping using a novel approach for motion compensation at 3T.
All patients underwent cardiovascular magnetic resonance (CMR) on a 3T system (Philips Ingenia). T1 maps were acquired in the basal and mid-cavity short-axis level, pre- and 20-min post-contrast (Gadovist 0.1 mmol/kg) with a 5s(3s)3s and 4s(1s)3s(1s)2s MOLLI acquisition scheme, respectively. A modified non-rigid, non-parametric registration method consisting of elastic registration steps was applied to generate motion-corrected T1 maps and subsequent ECV maps . T1 error maps and overlay images were used as an indication for quality control. Global ECV values were expressed as mean+/-standard deviation (SD).
Automated motion correction and co-registration improved the quality of T1 and ECV maps at 3T, making ECV mapping feasible for clinical application.
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