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Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

Abnormal regional myocardial morphology in patients with left ventricular pressure overload and preserved ejection fraction detected by multiparametric MR tissue mapping

Background

Abnormal myocardial morphology of the left ventricle (LV) may be relevant in patients with LV pressure overload for developing heart failure despite having preserved ejection fraction. We aimed to detect subclinical myocardial tissue changes in patients with aortic stenosis (AS) and hypertensive heart disease (HYP) by quantitative cardiovascular magnetic resonance.

Methods

Forty-eight patients with pressure overload (33 AS, 15 HYP and LV septum thickness ≥13 mm) and 60 healthy controls were enrolled. T1-maps (modified Look-Locker inversion recovery) and T2-maps (3 steady-state free-precession images with different preparation times) were obtained in a basal, mid-ventricular and apical short-axis slice. T1-maps were repeated after Gadobutrol i.v. T1- and T2-relaxation times and the partition coefficient were determined for every segment. Focal fibrosis was assessed with late enhancement images (LGE).

Results

Figure 1 shows the T2- and T1-relaxation times as well as the partition coefficient for each segment. Figure 2 provides a synopsis of the abnormal segments separated for AS severity grades. In AS, post-contrast T1-values were reduced at the base (septum, inferolateral) indicating fibrosis, in the septum even without the presence of LGE. Apical segments differed from controls by reduced T2- and native T1-values and partition coefficient, indicating abnormal regional tissue composition. With increasing AS severity, the number of segments with abnormal tissue composition increased. In HYP, post-contrast T1-values were abnormal in the basal septum indicating fibrosis, even without the presence of LGE. Partition coefficient and T2-relaxation times were reduced in the apex compared to controls.

Figure 1
figure1

Mean ± SD of T 2 - and T 1 -relaxation times and partition coefficient per segment. Segments that differed significantly from healthy controls are marked "*" and highlighted in orange.

Figure 2
figure2

Synopsis of abnormal findings when comparing each AS severity grade with healthy controls.

Conclusions

Severe AS, but also moderate AS and - to less extent - HYP exhibit abnormal regional tissue composition. Multiparametric segmental mapping has potential to detect organ damage at an early stage.

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Correspondence to Florian von Knobelsdorff-Brenkenhoff.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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von Knobelsdorff-Brenkenhoff, F., Mueller, A., Prothmann, M. et al. Abnormal regional myocardial morphology in patients with left ventricular pressure overload and preserved ejection fraction detected by multiparametric MR tissue mapping. J Cardiovasc Magn Reson 18, P336 (2016). https://doi.org/10.1186/1532-429X-18-S1-P336

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Keywords

  • Partition Coefficient
  • Cardiovascular Magnetic Resonance
  • Aortic Stenosis
  • Pressure Overload
  • Preserve Ejection Fraction