- Poster presentation
- Open Access
Abnormal regional myocardial morphology in patients with left ventricular pressure overload and preserved ejection fraction detected by multiparametric MR tissue mapping
© von Knobelsdorff-Brenkenhoff et al. 2016
- Published: 27 January 2016
- Partition Coefficient
- Cardiovascular Magnetic Resonance
- Aortic Stenosis
- Pressure Overload
- Preserve Ejection Fraction
Abnormal myocardial morphology of the left ventricle (LV) may be relevant in patients with LV pressure overload for developing heart failure despite having preserved ejection fraction. We aimed to detect subclinical myocardial tissue changes in patients with aortic stenosis (AS) and hypertensive heart disease (HYP) by quantitative cardiovascular magnetic resonance.
Forty-eight patients with pressure overload (33 AS, 15 HYP and LV septum thickness ≥13 mm) and 60 healthy controls were enrolled. T1-maps (modified Look-Locker inversion recovery) and T2-maps (3 steady-state free-precession images with different preparation times) were obtained in a basal, mid-ventricular and apical short-axis slice. T1-maps were repeated after Gadobutrol i.v. T1- and T2-relaxation times and the partition coefficient were determined for every segment. Focal fibrosis was assessed with late enhancement images (LGE).
Severe AS, but also moderate AS and - to less extent - HYP exhibit abnormal regional tissue composition. Multiparametric segmental mapping has potential to detect organ damage at an early stage.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.