- Poster presentation
- Open Access
Comparison of heart deformation analysis and cine DENSE in volunteers and heart failure patients
© Auger et al. 2016
- Published: 27 January 2016
- Left Ventricle
- Left Bundle Branch Block
- Circumferential Strain
- Mechanical Dyssynchrony
- Left Ventricle Remodel
Post-processing methods have been developed to quantify myocardial strain from steady-state free-precession (SSFP) cine images. In the left ventricle (LV), global strain measurements from SSFP in healthy volunteers1,2 and in some types of heart disease compare favorably with myocardial tagging as a reference. We compared heart deformation analysis (HDA) of SSFP images and cine Displacement Encoding with Stimulated Echoes (DENSE) for the assessment of global and segmental circumferential strain (Ecc) and derivative indices in healthy volunteers and heart failure (HF) patients with left bundle branch block (LBBB).
Imaging was performed on a 1.5T Siemens Avanto MR system in 3 short-axis planes in 6 volunteers and 29 patients with HF-LBBB. Ecc was computed from SSFP images using HDA (Trufi Strain, Siemens Healthcare, Erlangen) and from cine DENSE using previously described methods3,4. The mean and standard deviation of global Ecc were compared and the correlation between HDA and cine DENSE was assessed. The circumferential uniformity ratio estimate computed with singular value decomposition (CURE-SVD) is a quantitative index of mechanical dyssynchrony based on segmental Ecc, where values near 1 indicate synchrony and lower values indicate dyssynchrony5. CURE-SVD was computed for all subjects using HDA and DENSE
HDA and cine DENSE show good agreement for global Ecc. For regional Ecc, HDA shows greater variability including apparent false-positive segmental dysfunction in some volunteers. While HDA measurements of dyssynchrony can discriminate HF-LBBB from healthy volunteers (p < 0.01), it underestimates the degree of synchrony in volunteers and the degree of dyssynchrony in patients compared to cine DENSE. CURE-SVD by cine DENSE has a better correlation to LV remodeling compared to HDA.
- Hor K, et al: JACC. 2010, 3 (2): P46-51.Google Scholar
- Morton G, et al: JCMR. 2012, 14: 43-Google Scholar
- Spottiswoode , et al: IEEE TMI. 2007, 26: 15-30.Google Scholar
- Spottiswoode , et al: MIA. 2009, 13: 105-115.Google Scholar
- Ramachandran , et al: Radiology. 2015, 275 (2): 413-20.PubMed CentralView ArticlePubMedGoogle Scholar
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