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Characterization of myocardial edema in rats with acute reperfused myocardial infarction at multiple time points by 7 T MR
© Chen et al. 2016
- Published: 27 January 2016
- Myocardial Infarction
- Acute Myocardial Infarction
- Late Gadolinium Enhancement
- Ventricular Remodel
- Ventricular Myocardium
Intramyocardial hemorrhage(IMH) caused by reperfusion after acute myocardial infarction (MI) is considered to be an important independent predictor of adverse left ventricular remodeling and clinic outcomes. We aimed to characterize the evolution of myocardial edema (ME) in rats with acute reperfused MI, and to explore the effect of IMH post reperfusion on ME.
MI model was induced on 17 Sprague-Dawley rats (female, 260-280 g) by ligating the left anterior descending or circumflex coronary arteries for 60 minutes, followed by reperfusion. The rats were then scanned in a 7 T MRI system at 24 h, 48 h, 72 h, and 5 d after reperfusion. Area of ME and T2 values of ME were measured on T2 mapping images. Myocardial infarction was validated by the late gadolinium enhancement (LGE) method. IMH was detected by T2w. Repeated measures analysis of variance and independent sample t test were used for statistical analysis.
Myocardial edema in rats after acute reperfused myocardial infarction with or without IMH evolves differently over time, hemorrhagic infarction indicates more severe myocardial damages than non-hemorrhagic infarction, with more extent and more severity of myocardial edema.
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