- Poster presentation
- Open Access
Border sharpness of scar tissue after myocardial infarction as determined by self-navigated free-breathing isotropic 3D whole-heart inversion recovery magnetic resonance
Journal of Cardiovascular Magnetic Resonance volume 18, Article number: P74 (2016)
The border zone of myocardial scar after myocardial infarction (MI) plays an important role for arrhythmia formation. For this reason, high-resolution 3D information of scar tissue for planning of electrophysiological interventions after MI is highly desirable. This study evaluates sharpness of the borders (SB) of scar after MI by a self-navigated isotropic 3D free-breathing whole-heart magnetic resonance with inversion recovery (3DSN-IR) in comparison to a standard 2D inversion recovery sequence.
Patients after MI detected by 2D late gadolinium enhancement (2D LGE) on a standard 2D inversion recovery sequence (resolution 1.3 mm2, 8 mm slice thickness) underwent 3DSN-IR on a 1.5T cardiac magnetic resonance scanner (MAGNETOM Aera, Siemens). Data acquisition was performed during the most quiescent systolic phase with a prototype 3D radial trajectory with self-navigation  after administration of 0.2 mmol/kg of Gadobutrol. A non-selective IR pulse was added prior to each acquired k-space segment to the segmented, ECG-triggered, fat-saturated radial SSFP imaging sequence with an isovolumetric resolution of 1.15 mm3. Inversion time was assessed with a 2D radial scout scan prior to 3DSN-IR. To determine SB, a customized software was used to calculate signal intensity gradients between two regions . SB in mm-1 of borders "blood pool to scar", "blood pool to non-infarcted myocardium" and "scar to non-infarcted myocardium" were compared between a 2D LGE short-axis slice with 8 mm slice thickness and two corresponding reconstructed 3DSN-IR short-axis slices, one with isovolumetric voxel size (1.15 mm3) and the second interpolated to 8 mm slice thickness, all at the same anatomical location.
Thirteen patients (5 females, 58 ± 10 y, time between 2D LGE and 3D LGE 59 ± 64 days) were included. All scars visualized by 2D LGE could be identified by 3DSN-IR. SB was significantly better in 3DSN-IR compared to 2D LGE for the borders "blood pool to non-infarcted myocardium" and "scar to non-infarcted myocardium". There was a trend to a better SB for 3DSN-IR images for the border "blood pool to scar" (see table and figure).
High resolution 3DSN-IR improves delineation of myocardial scar after MI as expressed by increased border sharpness in comparison to 2D LGE.
Piccini D, et al: Respiratory self-navigation for whole-heart bright-blood coronary MRI: methods for robust isolation and automatic segmentation of the blood pool. Magn Reson Med. 2012, 68 (29): P75-9.
Kording F, et al: Doppler ultrasound compared with electrocardiogram and pulse oximetry cardiac triggering: A pilot study. Magn Reson Med. 2014
About this article
Cite this article
Rutz, T., Ginami, G., Piccini, D. et al. Border sharpness of scar tissue after myocardial infarction as determined by self-navigated free-breathing isotropic 3D whole-heart inversion recovery magnetic resonance. J Cardiovasc Magn Reson 18, P74 (2016). https://doi.org/10.1186/1532-429X-18-S1-P74
- Myocardial Infarction
- Cardiac Magnetic Resonance
- Late Gadolinium Enhancement
- Blood Pool
- Magnetic Resonance Scanner