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- Open Access
Fermi function constrained deconvolution underestimates myocardial blood flow and myocardial perfusion reserve regardless of saturation correction of arterial input curve
© Yamada et al. 2016
- Published: 27 January 2016
- Myocardial Blood Flow
- Arterial Input Function
- Myocardial Perfusion Reserve
- Fermi Function
- Tracer Kinetic Modeling
Myocardial blood flow (MBF) can be quantified from arterial input function (AIF) and myocardial output function in perfusion MRI by using tracer kinetic modeling. Fermi function constrained deconvolution has been widely used to determine MBF and myocardial perfusion reserve (MPR). However, stress MBF and MPR in healthy subjects quantified by the Fermi deconvolution approach were reported to be 2 to 3 mL/min/g and 2 to 3, respectively, which are substantially smaller than those quantified by 15O-water PET (3 to 5 mL/min/g and 3 to 5, respectively). Tissue compartment model analysis with Patlak plot is an alternative approach to estimate MBF and MPR. In a recent study employing corrections for AIF saturation and extraction fraction of gadolinium contrast medium, MBF and MPR by model-based Patlak plot method showed an excellent agreement with those quantified by 15O-water PET. In the current study, we compare MBF and MPR calculated by Fermi function constrained deconvolution with those by model-based Patlak plot method.
Nine subjects (6 men, 65.1 ± 6.8 years) with normal coronary arteries were evaluated with a 3.0T MR system. First-pass perfusion MR images were obtained with a saturation recovery TFE sequence every heart beats. In order to perform saturation correction of the blood signal, we initially obtained first-pass MR images by administrating 10x diluted Gd-DOTA (0.003 mmol/kg). Then first-pass MR images were acquired at rest and during ATP stress with a Gd-DOTA dose of 0.03 mmol/kg. MBF was quantified by a Fermi constrained deconvolution with and without AIF saturation correction using an AHA 16 segment model. MBF was also calculated by model-based Patlak plot method with the corrections of AIF saturation and extraction fraction of gadolinium contrast medium.
The current results demonstrated that Fermi function constrained deconvolution underestimates MPR regardless of saturation correction of arterial input function.
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