Skip to content


Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

  • Poster presentation
  • Open Access

The evolution of myocardium at risk by T2-STIR MR imaging the first week after acute myocardial ischemia

  • 1,
  • 2,
  • 1, 3,
  • 4,
  • 5, 6,
  • 9,
  • 2,
  • 4,
  • 7,
  • 1, 8,
  • 1,
  • 1 and
  • 1
Journal of Cardiovascular Magnetic Resonance201618 (Suppl 1) :P94

  • Published:


  • Myocardial Infarction
  • Percutaneous Coronary Intervention
  • Acute Myocardial Infarction
  • Infarct Size
  • Cardiac Magnetic Resonance


Myocardial salvage is currently being used as endpoint in several clinical trials and is determined by relating final infarct size to myocardium at risk (MaR). T2-weighted imaging (T2-STIR) cardiac magnetic resonance (CMR) has previously been shown to enable assessment of MaR up to one week after acute myocardial infarction. Recent experimental data indicate that the extent of MaR by T2-STIR varies over the first week which would have implications on how to design clinical cardioprotection trials using myocardial salvage as endpoint and in the clinical diagnosis of patients with myocardial infarction and normal coronary arteries.

To investigate whether MaR as assessed by T2-STIR differs depending on scan day during the first week after the acute event in patients with reperfused first-time myocardial infarction.


196 STEMI-patients from the MITOCARE and CHILL-MI trials undergoing acute percutaneous coronary intervention were included in the study. Eight additional patients with CMR on day 1 were also included. T2-STIR MR imaging was performed 1-7 days after the acute event and was used to evaluate MaR. Diagnostic quality on a scale from 0-3 and ability to correctly assign culprit vessel compared to angiography.


There was no significant difference in MaR over the first week (p = 0.44, Figure 1A) neither was there any change in diagnostic quality (p = 0.26, Figure 1B). The rate of correctly assigned culprit vessel was also similar for the different scan days (Figure 1C).
Figure 1
Figure 1

MaR by T2-STIR over the first week. A) MaR as % of LV mass over time; B) diagnostic image quality over time; and C) Ratio of correctly assigned culprit vessel compared to angiography over time. Note that there is no significant change in MaR during the first week in any of the above aspects. Open and closed circles show mean values of MaR by CE-SSFP and T2-STIR respectively. Error bars show 1 standard deviation. MaR=Myocardium at risk, LV=Left ventricular mass, T2-STIR= T2-weighted short tau inversion recovery, CE-SSFP = contrast enhanced steady state free precession, LGE=late gadolinium enhancement.


Myocardium at risk by T2-STIR CMR imaging do not change in humans over the first week after acute reperfused myocardial infarction suggesting that MaR is a stable measure during this period of time.

Authors’ Affiliations

Department of Clinical Physiology, Clinical Sciences, Lund University, Lund, Sweden
University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria
Department of Biomedical Engineering, Faculty of Engineering, Lund University, Lund, Sweden
Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden
Department of Heart Disease, Haukeland University Hospital, Bergen, Norway
Department of Biomedicine, University of Bergen, Bergen, Norway
Department of Cardiology B, Oslo University Hospital Ullevål and University of Oslo, Oslo, Norway
Laboratory of Medical Informatics, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
Section for Interventional Cardiology, Department of Cardiology, Oslo University Hospital, Ullevål, Oslo, Norway


© Nordlund et al. 2016

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.