Comparison of T2-preparation and magnetization-transfer preparation for black blood delayed enhancement
© Jenista et al. 2016
Published: 27 January 2016
A fundamental component of the CMR exam is contrast enhanced imaging, which is crucial for delineating diseased from normal tissue. Unfortunately, diseased tissue immediately adjacent to blood often is hidden since there is poor contrast between hyperenhanced tissue and bright blood. A new method recently described, Flow-Independent Dark-blood DeLayed Enhancement technique (FIDDLE), allows visualization of tissue enhancement while suppressing blood signal. One critical part of FIDDLE is the prep pulse prior to inversion, which accentuates differences in magnetization between tissue and blood. In this study, we compared a T2-prep and a magnetization transfer (MT) prep for use with FIDDLE.
The components of FIDDLE are, (1) a prep pulse that differentially saturates tissue compared with blood (e.g. MT or T2); (2) phase-sensitive inversion recovery (PSIR); and (3) inversion time (TI) selection under condition: blood MZ < tissue MZ. T2-prep or MT-prep FIDDLE were compared in a canine model of MI (n = 9) and in MI patients (n = 3). The two sets of FIDDLE images were acquired in an interleaved fashion 10-20 mins after gadolinium administration (0.2 mmol/kg) using identical parameters. Images were visually graded for overall quality, and for visible blood pool artifacts. Additionally, images were analyzed by placing ROIs in the ventricular and atrial blood pool, and over the entire heart (blood pool and myocardium in all chambers). The magnitude of blood pool artifacts were calculated by assessing the percent variation in blood pool signal and normalizing this to the standard deviation of the signal from the entire heart.
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