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CMR-based 3D statistical shape modelling reveals left ventricular morphological differences between healthy controls and arterial switch operation survivors
© Bruse et al. 2016
- Published: 27 January 2016
- Left Ventricular Ejection Fraction
- Partial Little Square
- Cardiovascular Magnetic Resonance
- Arterial Switch Operation
- Statistical Shape Modelling
Left ventricular ejection fraction (LVEF) late after arterial switch operation (ASO) is often normal. However, some studies have shown increased indexed end diastolic volume (iEDV) and ventricular mass when compared to healthy controls. We sought to identify LV morphological differences between patients with transposition of the great arteries (TGA post ASO) and matched healthy control subjects. We hypothesised that besides a mere increase in ventricular volume, characteristic shape features can be associated with LV morphology post ASO. Ventricular shape being difficult to quantify using traditional morphometrics, a novel, validated non-parametric statistical shape modelling framework (SSM) was used to analyse 3D anatomical models without the need for landmarking.
Using a SSM framework based on CMR, distinct 3D shape features could be associated with LV morphology post ASO. Moreover, those shape features were linked with higher iEDV. Such advanced post-processing of CMR data could lead to identifying previously unknown 3D shape features of cardiac anatomy that distinguish healthy and diseased subjects, thereby constituting novel shape biomarkers for improved CMR-based diagnosis.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.