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Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

  • Walking poster presentation
  • Open Access

Pulmonary blood volume variation indexed to stroke volume and perfusion gradients: novel diagnostic tools in heart failure

  • 1,
  • 1,
  • 1 and
  • 1
Journal of Cardiovascular Magnetic Resonance201618 (Suppl 1) :Q23

  • Published:


  • Heart Failure
  • Stroke Volume
  • Pulmonary Vein
  • Cardiac Magnetic Resonance
  • Cardiac Resynchronization Therapy


Heart failure (HF) is a condition characterized by increased filling pressures in the left ventricle due to altered cardiopulmonary blood flow. However, there are no clinically available non-invasive quantitative methods to measure filling pressures in HF. The pulmonary blood volume variation (PBVV) indexed to stroke volume (SV) by cardiac magnetic resonance (CMR) could be a novel non-invasive measure of HF. However, the relationship between PBVV/SV and increased filling pressures has not been validated. We have previously shown that the effect of increased filling pressures and redistribution of pulmonary blood flow can objectively be quantified using perfusion gradients derived from ventilation/perfusion single-photon emission computed tomography (V/P SPECT). V/P SPECT perfusion gradients have a high positive predictive value to diagnose decompensated HF.

The aim of this study was therefore to investigate the relationship between the PBVV/SV and perfusion gradients in patients with heart failure.


Fifteen patients with HF (NYHA class 2-4, 2 women, 48-77 years) were included. All patients underwent CMR at 1.5T and V/P SPECT. Four patients were under consideration for heart transplantation and 11 patients were candidates for cardiac resynchronization therapy. By measuring the blood flow in the pulmonary trunk and in one pulmonary vein, the PBVV was calculated, defined as the maximum cumulative difference in pulmonary blood volume over one heart beat. The SV by CMR was measured as the integral of the flow measurement over one heart beat in the pulmonary trunk. Dorso-ventral perfusion gradients (%-counts/cm) were automatically derived from V/P SPECT images using a user independent algorithm previously developed and validated in our department.


There was a positive relationship between PBVV/SV and perfusion gradients (Figure 1) suggesting that PBVV/SV could be valuable in the diagnosis of HF.
Figure 1
Figure 1

Pulmonary blood volume variation indexed to stroke volume versus perfusion gradients in patients with moderate - severe heart failure. The solid line represents the fitted exponential curve.


PBVV/SV measured by CMR, as well as perfusion gradients by V/P SPECT have the potential to serve as non-invasive measures of HF. Further validation work with comparison to invasive pressure measurements are needed to assess the accuracy of the methods.

Authors’ Affiliations

Department of Clinical Physiology, Skane University Hospital, Lund University, Lund, Sweden


© Al-Mashat et al. 2016

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.