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Reproducibility of late gadolidium enhancement of atrial ablation scar
© Chubb et al. 2016
- Published: 27 January 2016
- Pulmonary Vein
- Late Gadolinium Enhancement
- Pulmonary Vein Isolation
- Scar Assessment
- Pulmonary Vein Isolation Procedure
Late gadolinium enhancement (LGE) can be used to visualise post-ablation scar in the left atrium, such as following pulmonary isolation procedures for atrial fibrillation. Studies have demonstrated a correlation between ablation site, LGE scar formation and clinical outcomes. However, the reproducibility of scar imaging is undetermined.
Eleven patients with atrial fibrillation (AF, 4 persistent) underwent first time pulmonary vein isolation procedure. 3D LGE magnetic resonance imaging (1.5T Philips Ingenia) was performed at 3 months (91 ± 15 days) post ablation (scan 1), with a reproducibility scan three days later (scan 2). 3D LGE acquisitions were performed at 10, 20 and 30 min post gadolinium (Gd, 0.2 mmol/kg) (spatial resolution 1.3 × 1.3 × 4 mm, reconstructed to 0.6 × 0.6 × 2 mm). Scan 2 was performed 48-96 hours after the Scan 1.
The left atrium (LA) was manually segmented and LGE enhancement projected onto the shell (maximum intensity projection technique). Each pulmonary vein (PV) was analysed by 4 independent observers. The percentage of scar encirclement of each PV was quantified visually between 0% (no scar) and 100% (complete encirclement of vein by scar). The LA shell was thresholded at 3.3 standard deviations above the blood pool mean.
Pulmonary vein encirclement was moderately reproducible. On assessment of maximum encirclement of each individual vein (the higher figure for each vein at either 20 min or 30 min post Gd), mean error between Scan 1 and Scan 2 was 2.0 (± 10.9)%. For mean encirclement, averaging measurements for each vein at 20 min and 30 min, mean error was 0.7% (± 18.4%).
The utility of LGE assessment of left atrial scar following ablation in guiding further interventions has varied between centres, and a study of the reproducibility of LGE assessment of atrial scar is clearly required. This study suggests that there is a good degree of reproducibility, but that it is highly dependent upon the timing of the acquisition following gadolinium administration. Current data suggests that the main shortfall of LGE scar assessment is one of sensitivity of scar detection, rather than specificity. An approach of multiple acquisitions, and assessment of maximum scar, may be the most reproducible.
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