- Walking poster presentation
- Open Access
Aortic flow and wall shear stress in aortic stenosis is associated with left ventricular remodeling
© von Knobelsdorff-Brenkenhoff et al. 2016
- Published: 27 January 2016
- Wall Shear Stress
- Aortic Stenosis
- Left Ventricular Remodel
- Aortic Blood Flow
- Left Ventricle Mass
Aortic stenosis (AS) can lead to highly variable stress for the left ventricle (LV) and consequently a broad range of LV remodeling. We hypothesize that changes in aortic blood flow caused by AS can contribute to cardiac afterload. The aim of this study was to describe the blood flow patterns in the ascending aorta in patients with AS and to determine its association with LV remodeling.
Thirty-seven patients with AS (14 mild, 8 moderate, 15 severe, age 63 ± 13 years) and 37 healthy, age- and gender-matched controls (age 60 ± 10 years) were prospectively enrolled to undergo 4D-flow MRI of the aorta. Vorticity and helicity were graded as absent, mild or marked using time-resolved 3D pathlines. Eccentricity of the peak blood flow velocity was evaluated as absent, mild or marked using a 2D plane in the mid-ascending aorta, and flow displacement from the vessel center was calculated. Peak systolic wall shear stress (WSSpeak) was quantified at the sinotubular level, mid-ascending and distal ascending aorta. LV remodeling was defined as increased ratio of LV mass by enddiastolic volume (relative wall mass, RWM).
AS leads to significantly abnormal vorticity, helicity and eccentricity as well as WSSpeak distribution in the ascending aorta. LV remodeling correlated with the extent of abnormal blood flow.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.