Validation of a novel dark-blood delayed enhancement technique for the detection of papillary muscle scar

Papillary muscle scarring may result in mitral regurgitation and may be foci for ventricular arrhythmias. However, papillary muscle scarring may be difficult to detect with delayed enhancement MRI (DE-MRI) since there is often poor contrast between hyperenhanced tissue and immediately adjacent bright blood pool. We have developed a new, Flow-Independent Dark-blood DeLayed Enhancement technique (FIDDLE) that increases conspicuity of areas of myocardial scar adjacent to the blood pool. We validated FIDDLE in detecting papillary muscle scar in an animal model of myocardial infarction (MI) and demonstrate feasibility in patients with MI.

We used a canine model of MI which results in both papillary muscle and LV wall infarction. CMR was performed 1 week to 6 months following MI at 3T (Siemens Verio). FIDDLE and standard DE-MRI were acquired in an interleaved fashion 10-20 minutes after Gadolinium administration (0.2 mmol/kg) using matched parameters (eg. slice thickness: 7 mm, in-plane resolution: 1.2 × 1.0, etc.). Following CMR, hearts were stained with triphenyltetrazolium chloride (TTC) to provide a gold standard histopathology reference. FIDDLE and DE were performed blinded to subject identity and pathology. MI patients had enzymatically confirmed MI and x-ray coronary angiography confirmed the infarct related artery (IRA). In patients, imaging and analysis were performed similar to that for canines.