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Equivalence of conventional and fast late gadolinium enhancement (LGE) techniques for quantitative evaluation of fibrosis in ischemic and non-ischemic cardiac disease - Save the Time!
© Muehlberg et al. 2016
- Published: 27 January 2016
- Myocardial Infarction
- Standard Deviation
- Late Gadolinium Enhancement
- Hypertrophic Cardiomyopathy
Segmented single-slice/single-breath-hold 2D phase-sensitive inversion recovery (2D-PSIR) sequences are the gold standard for evaluation of myocardial fibrosis. Aim of this study was to assess the accuracy of novel free-breathing or single-breath-hold LGE sequences to detect and quantify myocardial fibrosis in patients with different entities.
Overall detection rates of fibrosis - compared to the gold standard - were not significantly lower for any of the fast LGE sequences: 3D-IR (83.06 ± 20.0%), 3D-SSFP bh (88.25 ± 18.5%), and 3D-SSFP nbh (86.48 ± 14.7%).
Acquisition times were significantly shorter for 3D-IR (23.2 s ± 8.2 s) and 3D-SSFP (21.8 s ± 7.2 s) as compared to 2D-PSIR (375.5 s ± 86.3 s).
Fast 3D-SSFP, 3D-IR and conventional segmented 2D-PSIR sequences are equivalent techniques for the assessment of myocardial fibrosis, independent of an ischemic or non-ischemic etiology. Due to the minimized acquisition time they shorten scan protocols by up to 6 minutes.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.