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Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

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Transcatheter real-time MRI guided myocardial chemoablation using acetic acid


In patients with ischemic cardiomyopathy, radiofrequency ablation for ventricular arrhythmias can have limited efficacy because of the mismatch between lesion depth and substrate thickness, and because radiofrequency-induced edema surrounding the lesion is reversible resulting in only temporary conduction block. We hypothesized that transcatheter needle injection under real-time magnetic resonance imaging (MRI) of caustic agents doped with gadolinium contrast could achieve deep targeted and irreversible myocardial ablation which could be assessed acutely.


Caustic agent (ethanol or acetic acid) was injected into the myocardium of 8 swine using MRI-conspicuous needle catheters incorporating loopless antennae for active visualization under real-time MRI. MRI and histological appearances of acute and chronic lesions were compared. An animal model of ischemic cardiomyopathy was created in 10 swine by sub-selective transcoronary ethanol administration into non-contiguous territories. The conductive isthmus between adjacent infarcts was targeted for chemoablation under direct real-time MRI guidance. Baseline and post-chemoablation electroanatomic mapping was performed under X-ray fluoroscopic guidance using a commercial system.


Ethanol caused stellate lesions with skip areas of normal myocardium, whereas acetic acid caused circumscribed lesions of irreversible necrosis. Acetic acid chemoablation lesions had identical geometry by in vivo and ex-vivo MRI late gadolinium enhancement and histopathology, immediately and after 12(7-17) days. In the animal model of ischemic cardiomyopathy, real-time MRI needle chemoablation successfully eliminated the conductive isthmus immediately by late gadolinium enhancement (Figure 1A-C), histologically (Figure 1D-F), and by electroanatomic voltage mapping (Figure 1G-J).

Figure 1
figure 1

Real-time MRI guided chemoablation of a conductive isthmus in a porcine model of ischemic cardiomyopathy.


Real-time MRI guided myocardial chemoablation with acetic acid is feasible and enables fully transmural substrate-targeted ablation by real-time visualization of arrhythmic substrate and immediate depiction of irreversible ablation lesions. Acetic acid creates more circumscribed and homogeneous lesions than ethanol. Using this technique, we demonstrate anatomical ablation of a conductive isthmus by late gadolinium enhancement and functional abolition of abnormal electrograms in an animal model of ischemic cardiomyopathy. Real-time MRI guided chemoablation could improve efficacy of arrhythmic substrate ablation in the thick ventricular myocardium.

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Rogers, T., Mahapatra, S., Kim, S. et al. Transcatheter real-time MRI guided myocardial chemoablation using acetic acid. J Cardiovasc Magn Reson 18 (Suppl 1), Q68 (2016).

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