Pressure gradient measurement using phase contrast (PC)-MRI in stenotic phantom models: Towards noninvasive quantification of fractional flow reserve in the coronary arteries
Journal of Cardiovascular Magnetic Resonance volume 18, Article number: W15 (2016)
Fractional flow reserve (FFR) is an invasive diagnostic tool to evaluate the functional significance of an intermediate coronary stenosis by quantifying the pressure gradient (ΔP) across that stenosis . Noninvasive ΔP measurement (ΔPMR) using phase-contrast (PC)-MRI in conjunction with Navier-Stokes (NS) equations has been attempted in large to medium size vessels [2–4], and recently been applied to smaller coronary arteries . However, the measurement accuracy awaits systematic validation given that the small, tortuous, and moving caliber in the coronary artery, particularly when a stenosis exists, may elicit errors in flow velocity quantification by PC-MRI. This study aimed to investigate the feasibility of deriving ΔPMR in small caliber stenotic phantom models at various diameters and its correlation with measured ΔP values via a pressure transducer (ΔPPT).
11 small caliber phantom models ranging from 0%-85% area stenosis, with a reference diameter of 4.8 mm, were individually connected to a flow pump (gadolinium-doped water, constant volume velocity = 250 mL/min) while 2D cross-sectional PC-MRI images were acquired. Contiguous slices (10-20) were consecutively collected across each narrowing (fig. 1a/b). Imaging parameters were: FA = 15°; TE/TR = ~4.0/70 ms; in-plane spatial resolution = ~0.55 × 0.55 mm2; slice thickness = 3.2 mm; Venc = z (40-260 cm/s) and x, y (40-80 cm/s), depending on the degree of narrowing. Eddy-current correction was done offline followed by NS calculations . Repeat scans were performed in 7/11 phantom models and reproducibility was assessed by calculating the intra-class correlation coefficient (ICC) and Bland-Altman plots. Immediately following the PC-MRI scans, pressure was measured using an arterial catheter connected to a pressure transducer at ~1.5 cm before and ~3 cm after the maximum narrowing of the phantom models.
Bland-Altman plots of peak velocities and ΔPMR are shown in fig. 2a. For velocity measurements, excellent correlation was seen in the through-plane peak velocities (Vz, ICC = 0.90) and lower in Vx (ICC = 0.57) and Vy (ICC = 0.58). For ΔPMRs, overall ICC = 0.87; When observed individually, higher correlation was seen at smaller stenosis degrees and weaker as stenosis increased (fig. 1b). This could be due to the increased velocity in larger stenosis, causing minor turbulence distal of the narrowing, thus, inconsistent velocity and ΔPMR between the two scans. Furthermore, ΔPMR and ΔPPT were highly correlated (fig. 2b). We also observed that as % area stenosis increased, ΔPMR also increased (fig. 2c).
Preliminary results suggest that quantification of ΔPMR in a small caliber is feasible. Further technical improvements in higher in-plane and through-plane spatial resolutions and reduction of noise need to be employed, which could potentially help improve the accuracy of the ΔPMR calculations.
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Deng, Z., Lee, S.E., Fan, Z. et al. Pressure gradient measurement using phase contrast (PC)-MRI in stenotic phantom models: Towards noninvasive quantification of fractional flow reserve in the coronary arteries. J Cardiovasc Magn Reson 18 (Suppl 1), W15 (2016). https://doi.org/10.1186/1532-429X-18-S1-W15