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Cardiovascular magnetic resonance feature tracking derived strain parameters in patients with acute myocarditis and preserved ejection fraction: a validation study
Journal of Cardiovascular Magnetic Resonance volume 18, Article number: W21 (2016)
The purpose of this study was to validate the diagnostic value of cardiovascular magnetic resonance (CMR) feature tracking (FT) derived strain parameters of both ventricles in patients with acute myocarditis (ACM) and preserved left ventricular ejection fraction (EF).
CMR data of 18 patients with clinically suspected ACM and confirmation of diagnosis by CMR according to the Lake Louise criteria (LL criteria) were retrospectively analyzed. 30 healthy volunteers (HV) served as a control. A second cohort consisting of 51 patients with clinically diagnosed ACM and preserved EF served as a validation cohort. All patients and HV were examined on a clinical 1.5T scanner. Analysis of global longitudinal (long.), circumferential (circ.) and radial strain and strain rate (SR) of both ventricles was performed in one long-axis and three short-axis slices using a dedicated FT-software (TomTec Imaging Systems). Statistical analysis was conducted using independent t-test, one-way ANOVA with tukey-type comparisons, multinominal logistic regression analyses, classification trees, and ROC-analyses.
Patients with CMR-proven ACM and preserved EF (n = 18) showed a significantly improved basal RV circ. SR compared to HV (-0.76 ± 0.05 vs. -0.47 ± 0.07 s-1, p = 0.005) while LV strain parameters showed no significant differences between both groups. In multinominal logistic regression analyses, LV circ. strain and basal RV circ. SR proved to be the best independent predictors of ACM when LV-EF is preserved with an AUC of 0.82 in ROC-analysis. In classification trees, a cut-off of -29.0% for LV circ. strain and of - 0.43 s-1 for basal RV circ. SR resulted in 80% sensitivity and 80% specificity for classification between HV and CMR-proven ACM with preserved EF.
Applying these cut-offs on the validation cohort (n = 51) resulted in a moderate diagnostic sensitivity of 56% and a specificity of 71%. A re-estimation of logistic regression models in the validation cohort showed that a combination of LV long. strain and basal RV circ. SR was superior in predicting ACM compared to the model containing LV circ. strain. In classification trees, a cut-off of -20.4% for LV long. strain and of - 0.37 s-1 for basal RV circ. SR resulted in 77% sensitivity and 80% specificity for classification between HV and ACM with preserved EF.
In ROC-analyses, the combination of LV long. strain and basal RV circ. SR showed superior diagnostic performance (AUC 0.82) when compared to LL criteria (AUC 0.76; Figure 1), and the combination of LV long. strain, basal RV circ. SR and Late Gadolinium Enhancement (LGE) further improved prediction of ACM with preserved EF with an AUC of 0.87.
The proposed cut-off values for LV long. strain and basal RV circ. SR show an additional diagnostic value to the established Lake Louise criteria and may serve as novel diagnostic parameters in the setting of ACM.
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Baessler, B., Schaarschmidt, F., Quellhorst, L. et al. Cardiovascular magnetic resonance feature tracking derived strain parameters in patients with acute myocarditis and preserved ejection fraction: a validation study. J Cardiovasc Magn Reson 18 (Suppl 1), W21 (2016). https://doi.org/10.1186/1532-429X-18-S1-W21
- Healthy Volunteer
- Left Ventricular Ejection Fraction
- Cardiovascular Magnetic Resonance
- Late Gadolinium Enhancement
- Classification Tree