- Workshop presentation
- Open Access
Initial experience with isotropic 3D cardiac T2 mapping for the monitoring of cardiac allograft rejection
© van Heeswijk et al. 2016
- Published: 27 January 2016
- Allograft Rejection
- Acute Allograft Rejection
- Cardiac Allograft Rejection
- Mild Rejection
Cardiac T2 mapping has been suggested for monitoring of acute allograft rejection, since the T2 relaxation time increases with myocardial edema . Besides its non-invasive nature, the main advantage of T2 mapping over the reference standard endomyocardial biopsy (EMB) is that it results in a higher spatial coverage of the myocardium. Currently established 2D techniques are used to acquire several slices in short- and long-axis orientation, which should suffice for the detection of moderate to severe rejection (ISHLT degree 2R-3R ), since the manifestation of edema is global. However, in the case of the more common mild rejection, the manifestation of edema is localized and patchy, and might thus be missed by a selective 2D visualization. We therefore investigated the performance of a novel 3D cardiac T2 mapping technique  for the detection of acute allograft rejection versus 2D T2 mapping and EMB.
28 Patients (age 54 ± 12 y, 24 males) underwent routine EMB as well as 2D and 3D cardiac T2 mapping at 3T. Navigator-gated 2D T2 maps  (voxel size 1.2 × 1.2 × 5 mm3) in 3 short-axis slices and a prototype self-navigated 3D radial whole-heart isotropic T2 map  (voxel size 1.7 mm3) were acquired with 3 T2-preparation durations and free breathing. After reformatting of the 3D T2 maps and matching for slice thickness, the 2D and 3D T2 maps at the same location were segmented according to AHA guidelines . The highest segmental 2D and 3D T2 values of each patient were compared statistically, and then divided into groups according to their EMB rejection degree. These groups were then tested for differences in T2 value. The 3D T2 maps were furthermore directly rendered in 3D, after which they were inspected for foci of T2 elevation.
The investigated 3D cardiac T2 mapping agreed with the established 2D technique, and enables the identification of foci of elevated T2 in regions of the myocardium that are not covered by the 2D technique. The 3D cardiac T2 mapping technique thus appears to be well-suited for the investigation of mild allograft rejection (degree 1R), but this remains to be confirmed in a larger patient cohort.
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