- Workshop presentation
- Open Access
BOLD contrast: A challenge for cardiac image analysis
© Oksuz et al. 2016
- Published: 27 January 2016
- Feature Vector
- Ground Truth
- Blood Oxygen Level Dependent
- Blood Oxygen Level
- Registration Accuracy
Blood oxygen level dependent (BOLD) imaging of the heart has been shown to assess ischemia at rest or benign non-invasive stress. However, since BOLD changes are not readily visible to the naked eye, post processing and analysis is necessary. But, BOLD contrast is modulated by the presence of disease and also by the imaging protocol and sequence, posing significant challenges in creating robust algorithms for analyzing such data.
We discuss recent approaches for automatically segmenting and registering cardiac-phase resolved CP-BOLD MRI studies.
We use CP-BOLD data from controlled canine (10) experiments imaged at rest, under baseline and severe LAD occlusion (ischemia). We delineate manually all myocardial borders to have ground truth. Based on these delineations we learn dictionaries (examples shown in Figure 1a) to describe a given patch (a small square image block) with as few (ie., sparse) linear combinations of templates as possible. The coefficients of those combinations form a feature vector for each patch, and can describe it while remaining unaffected by the BOLD contrast. We use such feature vectors for myocardial segmentation by optimizing a non-linear classifier but also for non-linear registration to correct for myocardial motion in this cine-type acquisition. We define, and use within our algorithm, a new similarity metric that compares how close those features are between patches belonging to target and reference images.
We follow a leave 1 out crossvalidation strategy: we use 9 canines to learn dictionaries and we use our methods to segment and register the images of the other canine. (We do this separately for baseline and ischemia). We use the Dice metric that measures overlap between the automatically obtained segmentation vs. the ground truth. We use Dice to also evaluate registration by propagating the segmentation mask of end diastole (reference) of the cardiac cycle to all others (target) and compare the propagated mask with the one in the ground truth.
We outlined a series of algorithms that can segment, register and analyze these datasets. While more evaluation is necessary, BOLD does provide unique opportunities to study the heart without any contrast and stress.
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