- Workshop presentation
- Open Access
Myocardial strain analysis with CMR in cardiotoxicity patients using deformation field analysis: Comparison to healthy volunteers and heart transplant patients
© Bogachkov et al. 2016
- Published: 27 January 2016
- Circumferential Strain
- Strain Data
- Siemens Medical System
- Heart Transplant Patient
- Lagrangian Strain
Noninvasive monitoring of cardiac function in patients with iatrogenic or environmentally-induced cardiotoxicity is of prime importance as a measure of disease severity. Strain imaging at cardiac MR (CMR) has been previously shown to be a highly robust modality in the detection of early cardiac dysfunction in the heart failure population. However, strain analysis has not previously been applied in the assessment of cardiotoxicity patients. The purpose of this study is to compare radial and circumferential LV strain values in patients with known cardiotoxicity to healthy volunteers and post-heart transplant patients, and to then correlate the cardiotoxicity strain values to calculated LV ejection fractions.
Retrospective analysis of CMR images from 11 volunteers (9/11 males, avg. age 51.6), 5 heart transplant patients (5/5 males, avg. age 60.2), and 10 cardiotoxicity patients (3/10 males, avg. age 48.9) were obtained at 1.5 T (MAGNETOM Avanto, Siemens Medical Systems, Erlangen, AG) using GRAPPA factor 2 acceleration. Myocardial strain analysis at CMR was performed using semi-automatic prototype software calculating Lagrangian strain from deformation field analysis (Siemens Corp, Corporate Technology, Princeton, NJ). Left ventricular (LV) midwall average and peak systolic radial and circumferential strains data was calculated. Strain data between groups was compared using univariate analysis of variance (ANOVA) to assess statistical equivalence. Cardiotoxicity patients' strain data was compared to calculated LVEF values using linear regression with associated R2 values.
Radial and circumferential LV strain values in patients with known cardiotoxicity were found to be lower than volunteers in a statistically significant manner when using a semi-automatic prototype software calculating Lagrangian strain from deformation field analysis. Furthermore, strain values were found to correlate strongly with LVEF, a well-established clinical marker of cardiotoxicity, particularly in the mean average-segmental peak radial and circumferential strain values. Continued work is necessary to elucidate a more defined clinical role for CMR-calculated strain in the cardiotoxicity patient population.
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