- Workshop presentation
- Open Access
Quantification of coronary vessel wall thickness using a flexible time-resolved golden angle dual-inversion recovery acquisition for facilitated sequence timing at 3T
© Ginami et al. 2016
- Published: 27 January 2016
- Double Inversion Recovery
- Trigger Delay
- Vessel Wall Thickness
- Coronary Vessel Wall
- Radial Acquisition
Positive vessel wall remodeling is an early marker of coronary artery diseases. Its early detection could improve prognosis of adverse cardiovascular events. Black blood MRI based on double inversion recovery (DIR) (1) represents a non-invasive technique for the visualization of the coronary vessel wall. However, the need of collecting imaging data at the moment of both optimal blood signal nulling (2) and minimal myocardial motion, still limits the use of the technique in clinic. In order to alleviate difficulties in sequence planning, we propose a continuous acquisition scheme throughout a prolonged acquisition window. Combined with golden angle radial acquisition and k-t sparse SENSE (3), this enables a fully flexible a posteriori selection of imaging parameters.
The quantified vessel wall thickness remained unchanged among the two reconstructions (0.95 ± 0.27 for the baseline, and 0.97 ± 0.18 for the best frame, p = NS). Simultaneously, image quality improved (Fig 2) according to all the quantified end-point from the baseline to the best graded frame (VWS%: 24.2 ± 8.7% and 42.5 ± 7.0%, VWC: 5.6 ± 3.1 mm and 7.2 ± 0.2 mm, visual grading: 2.2 ± 1.0 and 3.4 ± 0.8, p < 0.03 in all cases). Furthermore, TD was found to be different from TDopt (665.7 ± 88.1 ms and 687.3 ± 92.7 ms, p < 0.01).
We successfully implemented a flexible technique for quantification of coronary vessel wall thickness which eliminates difficulties related to complicate acquisition planning of conventional BB DIR. With this technique, improved vessel wall delineation can be obtained. Patient studies are now warranted.
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