Fig. 4

Extraction of quantitative metrics from histogram analysis of liver and myocardial normalized intensity (NI, mean of all subjects) across the cardiac cycle for three steady state (SS) preparations. To generate a histogram, the normalized signal intensity of liver a and myocardial b signal intensity (SI) is plotted against the fraction of the cardiac cycle occupied by that normalized signal intensity level. When data are plotted in this manner, the mode of the histogram (circles) indicates the in vivo steady state normalized signal intensity level for each of the SS preparation methods. c, d: Cumulative density functions of histograms plotted in A and B are used to calculate the percentage of cardiac cycle spent below a specific normalized signal intensity level. Total percentage of cardiac cycle (PCC) spent close to steady-state level is defined as cumulative density function at 1.25*normalized signal intensity (vertical line) level (refer to legend in Fig. 2). Temporal signal intensity variation (SIV) is defined as the ratio of normalized signal intensity values at 95 and 5% (horizontal lines) of cumulative density function