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3T versus 1.5T MR angiography in peripheral arterial occlusive disease: an equivalence trial in comparison with digital subtraction angiography
© van den Bosch et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Digital Subtraction Angiography
- Popliteal Artery
- Superficial Femoral Artery
- Arterial Segment
- External Iliac Artery
Standardized single-injection 3-station moving-table 3T contrast-enhanced MR angiography (CE-MRA) is reliable for stenosis detection and classification in peripheral arterial occlusive disease with equivalent diagnostic performance as 1.5T CE-MRA, while contrast-to-noise ratio significantly increased at 3T for identical contrast dosage.
Contrast-enhanced MR angiography (CE-MRA) has evolved into a reliable imaging technique for peripheral arterial occlusive disease (PAOD). Recent advances in MRI technology offer large homogeneous magnetic fields with comparable Field-of-Views at 3T and 1.5T, allowing visualization of the complete runoff vascular tree by single-injection 3-station (pelvic/thigh/calf) moving-table CE-MRA. Diagnostic performance of 3T versus 1.5T CE-MRA has not yet been described. The purpose of this study was to compare diagnostic accuracy of 3T CE-MRA in POAD in an equivalence trial with 1.5T CE-MRA, with conventional digital subtraction angiography (DSA) as the standard of reference.
In nineteen patients (13 men; mean age 69 years), DSA and standardized single-injection 3-station moving-table CE-MRA with equivalent acquisition protocols and contrast dosage were performed at 3T and 1.5T MRI (Philips, Best, the Netherlands). For CE-MRA, 0.2 mmol/kg body weight gadoterate meglumine was injected, with the first half of the bolus at 2 mL/s and second half at 0.6 mL/s. At 1.5T, a quadrature body coil (QBC) was used for imaging pelvic and thigh stations and a 4-element phased array coil for calf station. At 3T, a QBC was used in all three stations. DSA was performed using iomeprol injection at variable volumes and flow rates depending on the arterial segment.
The arterial tree in each patient was divided into 27 segments, infrarenal aorta, common and external iliac arteries, common and superficial femoral arteries, popliteal arteries in thigh and calf station, tibiofibular trunk, proximal and distal halves of the anterior and posterior tibial arteries and peroneal arteries. Visual stenosis classification was performed in consensus by two radiologists in blinded manner using the following categories: class 1 (0%-stenosis), 2 (1-50%), 3 (51-75%), 4 (76-99%) and 5 (100%). Quantitative analysis of contrast-to-noise ratio (CNR) was performed for the external iliac artery and the superficial femoral artery.
Diagnostic performance for stenosis detection at 3T versus 1.5T contrast-enhanced MRA
Standardized single-injection 3-station moving-table 3T CE-MRA is reliable for stenosis detection and classification in POAD with equivalent diagnostic performance as 1.5T CE-MRA, while CNR significantly increased at 3T for identical contrast dosage.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.