- Oral presentation
- Open Access
Diastolic function from tagged MRI and myocardial fibrosis: the Multi-Ethnic study of Atherosclerosis (MESA)
© Venkatesh et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Diastolic Dysfunction
- Diastolic Function
- Myocardial Fibrosis
- Circumferential Strain
- Diffuse Myocardial Fibrosis
MRI-derived T1 times are associated with diffuse interstitial myocardial fibrosis. LV diastolic dysfunction and fibrosis are important components of cardiac disease, but their relationship has not been firmly established. Early diastolic strain rate (Epeak) has been validated as an indicator of diastolic function by tagged MRI. We derive a novel strain relaxation index (SRI) based on circumferential strain from tagged MRI to indicate early phases of diastolic dysfunction. SRI is defined as the ratio of very early myocardial relaxation time and tissue compliance. We will assess the relationship between diastolic dysfunction assessed by both SRI and Epeak with myocardial fibrosis.
1080 participants (52.7% women, mean age 67±9 years, 51% Caucasian, 12% Chinese-American, 22% African-American, 15% Hispanic) were considered and 97 excluded due to the presence of myocardial scar. Mean values for logSRI, logEpeak and T1 (12min) were 0.95±0.58 s, 0.11±0.04 /s and 455±40 ms respectively. SRI and post-contrast T1 times were inversely related (Table 1). This relation remained significant after adjustment for covariates in models 1 and 2. Epeak was not related to post-contrast T1 times in any of the models.
Coefficients (p-values) for linear regression between of SRI and Epeak (in logarithmic scale), and post-contrast T1 times at 12'. Model 1 included covariates glomerular filtration rate, pre-contrast T1 values adjusted to the heart rate, time difference between gadolinium injection and imaging, and gadolinium dosage in mmol/kg. Model 2 included adjustment for age, gender and ethnicity in addition to model 1 covariates.
Diastolic function parameter
Coefficient (p value)
Diffuse myocardial fibrosis as assessed by decreased T1 times was associated with worse diastolic function as assessed by increased values of SRI. SRI as a diastolic function marker is more sensitive to the presence of myocardial fibrosis than the conventionally used Epeak.
NHLBI grant - HL066075.
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