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  • Open Access

Age-gender reference values of native myocardial T1 at 1.5T and 3T: comparison of MOLLI and shMOLLI

  • 1,
  • 1,
  • 2,
  • 3,
  • 1 and
  • 1
Journal of Cardiovascular Magnetic Resonance201315 (Suppl 1) :P91

https://doi.org/10.1186/1532-429X-15-S1-P91

  • Published:

Keywords

  • Field Strength
  • Motion Correction
  • Recovery Sequence
  • Manual Motion
  • Inversion Recovery Sequence

Background

Native T1 mapping is promising non-invasive method for quantitative assessment of diffuse myocardial processes. The aim of the current study was to interrogate normal values for T1 measurement within native myocardium for age and gender using most commonly used sequences and field strengths.

Methods

Ninety-nine subjects with no history of cardiovascular or systemic disease or regular medication underwent native T1 imaging with modified (MOLLI; 3,3,5) and shortened modified look-locker inversion recovery sequence (shMOLLI; 1,1,5) at either 1.5T or 3T. The images were analyzed using an Osirix plug-in with manual motion correction of the ROI placed conservatively within the septal myocardium. For comparison, lateral myocardium and blood values were also derived.

Results

There was similar representation for age and gender across both field strengths (Table 1). Mean value for T1 native myocardial by MOLLI was higher than shMOLLI for septum and lateral ROI for both field strengths, p<0.01 for all). There was no significant difference for gender nor age-groups in T1 relaxation time for either MOLLI or shMOLLI imaging at either field strength.

Table 1

Population

1.5T n=47

3T n=52

Age (years)

39±13

39±14

Male (n,%)

26 (55)

28 (53)

MOLLI

  

Septum (msec)

943±45

1055±39

Lateral (msec)

917±55

1025±55

Blood (msec)

1594±111

1759±181

shMOLLI

  

Septum (msec)

833±55

894±74

Lateral (msec)

800±61

854±84

Blood (msec)

1554±210

1662±120

Age groups

  

MOLLI (septal values)

  

<30 years

944±50

1060±35

30-45 years

943±42

1046±44

>45 years

946±32

1038±32

shMOLLI (septal values)

  

<30 years

837±57

869±65

30-45 years

846±140

851±120

>45 years

840 ±47

912±82

Gender (septal values)

  

MOLLI

  

Male (msec)

945±44

1057±37

Female (msec)

942±50

1050±37

shMOLLI

  

Male (msec)

839±45

885±91

Female (msec)

846±57

878±84

Conclusions

We report age-gender normal values for native myocardial T1 mapping by the two most commonly used sequences and field strenghts. We show that there are neither gender differences in a cohort as a whole nor within separate age groups.

Funding

NIHR
Figure 1
Figure 1

T1 source images (A-K) as well as the T1 map (L) acquired in mid-ventricular short-axis slice. ROI placements within septum, lateral wall and blood pool (green marks). Image M shows the analyzed septal T1 relaxation time (red arrow).

Authors’ Affiliations

(1)
Cardiovascular Imaging, King's College London, London, UK
(2)
Philips Innovative Technologies, Clinical Research, London, UK
(3)
Medical Physics and Bioengineering, King's College London, London, UK

Copyright

© Dabir et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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