- Oral presentation
- Open Access
Quantification of intra and inter-ventricular dyssynchrony in Ebstein's anomaly using cardiovascular magnetic resonance myocardial feature tracking
© Steinmetz et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Right Ventricular
- Ventricular Performance
- Myocardial Strain
- Contraction Pattern
- Intraventricular Dyssynchrony
Ebstein's anomaly consists of varying degrees of tricuspid dysplasia and displacement into the right ventricular (RV) cavity, along with changes in ventricular function predominantly affecting the RV. Measuring alterations in contraction pattern and dyssynchrony may provide insights into ventricular performance in this disease. We sought to quantify right and left ventricular (RV and LV) deformation and dyssynchrony in a cohort of patients with Ebstein's anomaly in comparison with normal controls using cardiovascular magnetic resonance myocardial feature tracking (CMR-FT).
Twenty-six patients with uncorrected Ebstein's anomaly and 10 normal controls were prospectively studied. LV and RV global longitudinal myocardial strain (GLSLV and GLSRV) and time to peak strain (TPKLV and TPKRV) were calculated from the 4-chamber cine CMR images. Intraventricular dyssynchrony (IntraVD) was calculated as the difference between the segments with the longest and shortest TPK divided by the global TPK value of the respective ventricle: (IntraVD) = TPKlongest-TPKshortest/TPK global. The ratio of global TPKRV and TPKLV was measured as interventricular dyssynchrony (InterVD).
Strain values and times to peak in Ebstein's anomaly and normal controls.
Mean ± Standard Deviation
TPK GLS [ms]
TPK GLS [ms]
-17.2 ± 4.3
330 ± 58
-15.7 ± 5.2
338 ± 78
-17.7 ± 4.3
336 ± 36
-21.1 ± 2.9
338 ± 26
These results demonstrate RV intraventricular dyssynchrony and reduced global RV strain in Ebstein's anomaly that can be derived by CMR myocardial feature tracking. Larger studies are needed to understand the significance of these parameters in the disease progression and their clinical implications.
German Centre for Cardiovascular Research (DZHK Partner Site Göttingen).
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