- Poster presentation
- Open Access
Myocardial iron overload in thalassemia major. How early to check?
© Meloni et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Cardiovascular Magnetic Resonance
- Late Gadolinium Enhancement
- Myocardial Fibrosis
It is still controversy in thalassemia major (TM) if Cardiovascular Magnetic Resonance (CMR) T2* screening should be initiated before the 10 years. To answer this question, we studied retrospectively the prevalence of cardiac iron and function and myocardial fibrosis by CMR in a consistent cohort of TM patients younger than 10 years.
From the 2171 patients enrolled in the MIOT (Myocardial Iron Overload in Thalassemia) network, we retrospectively selected the 35 TM patients aged less than 10 years who had undergone at least one MRI scan. Myocardial iron overload (MIO) was measured by T2* multislice multiecho technique. Biventricular function parameters were quantitatively evaluated in a standard way by cine images. To detect myocardial fibrosis, late gadolinium enhancement images were acquired.
Demographic, clinical and MRI data of the 4 patients with global heart T2* < 20 ms.
Transfusions starting age (months)
Mean Hb pre-transfusion (g/dl)
Mean serum ferritin in the previous year (ng/ml)
Transfused iron (g)
Chelation starting age (months)
Chelation treatment at the time of MRI
Previous chelation therapy
Global heart T2*/Mid ventricular septum T2* (ms)
MRI CIC (mg/g dry weight)
N. of pathological segments
Pattern of MIO
MRI LIC (mg/g dry weight)
LV EF (%)
RV EF (%)
The first cardiac T2* assessment should be performed as early as possible without sedation and it is mandatory whenever poor compliance is suspected or if chelation has been started late.
The MIOT project receives "no-profit support" from industrial sponsorships (Chiesi Farmaceutici S.p.A. and ApoPharma Inc.). This study was also supported by: "Ministero della Salute, fondi ex art. 12 D.Lgs. 502/92 e s.m.i., ricerca sanitaria finalizzata anno 2006" and "Fondazione L. Giambrone".
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.