- Poster presentation
- Open Access
Assessing the reliability of DP and Fermi estimates in single and dual bolus cardiac MR perfusion imaging
© Papanastasiou et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Myocardial Perfusion Imaging
- Perfusion Imaging
- Distribute Parameter
- Arterial Input Function
- Single Bolus
MR dual bolus (DB) perfusion imaging has been effectively shown to eliminate signal saturation of the arterial input function (AIF) and allow more reliable quantification of myocardial (Myo) blood flow (MBF). Single bolus (SB) protocols are prone to AIF signal saturation but have been widely used in clinical studies. The Fermi model has been well established for MBF quantification. The distributed parameter (DP) model has been implemented in a recent study to measure additional physiological parameters (PP) such as intravascular (vb) and extravascular-extracellular space (ve) of the coronary arteries (CAs). Our study aims to a) validate absolute values, correlations and differences between SB versus DB estimates and b) assess which model more reliably fits SB data.
After informed consent, 8 healthy volunteers underwent adenosine stress-rest MR myocardial perfusion imaging (3T Verio, Siemens AG, Healthcare Sector). A dilute (0.006 mmol/kg) Gd-based contrast agent (Gadovist, Bayer Healthcare) was injected to allow extraction of the AIF for the DB analysis followed by a standard (0.03 mmol/kg) Gd dose for the extraction of Myo signal intensity curves (Ishida M et al. 2011). Images were acquired in mid-diastole. SB AIF data were generated by extracting the AIF from the standard Gd dose component of the DB data. Signal intensity AIF and Myo curves were converted to Gd concentration curves (Biglands J et al. 2011). The Fermi model (Jerosch-Herold M et al. 1998) was used to quantify MBF as a reference standard against DP-MBF (Broadbent et al. 2013). DP and Fermi values were examined both in SB and DB data. Bland Altman plots and paired t-test (p values < 0.01 were considered significant) were used for data analysis.
Parameter comparisons are shown in SB and DB data both at stress (S) and rest (R).
DP-MBF and PP values were not significantly affected when SB AIF was used which suggests that DP model might more reliably model SB data than Fermi. This should be further investigated in larger populations. PS was low compared to previous mid-systole analysis, suggesting that DP may show potential in detecting decreased permeability of the CAs in mid-diastole.
This work was made possible through funding and continued support from the British Heart Foundation.
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