- Workshop presentation
- Open Access
Unsupervised free-breathing 3-dimensional imaging of morphology, function and flow in congenital heart disease under 30 minutes: pilot study
© Krishnamurthy et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Congenital Heart Disease
- Image Quality Assessment
- Average Percentage Difference
- Blood Pool Contrast Agent
- Cine SSFP
Cardiac MRI for congenital heart disease (CHD) is an operator dependent and time-intensive examination requiring real-time decision making regarding choice of sequences, planes, and acquisition parameters to adapt to unique morphological and functional variables in a given patient.
To evaluate technical feasibility, image quality and quantitative integrity of a free-breathing (FB) protocol following administration of blood pool contrast agent, utilizing 3-dimensional (3D) imaging of morphology, function, and flow without physician supervision in a cohort of patients with CHD.
All FB 3D sequences were technically feasible in all 5 patients. Average time for completion of 5 FB 3D sequences was 29 minutes. Average score for first-pass MRA was 1.9/5. Average score for equilibrium MRA was 1.3/5. Clinical scores for 2D SSFP were consistently better than 3D-SSFP, but 3D SSFP images were adequate for recognition of pathology in all cases (2D vs 3D: 1.5 ± 0.5 vs 1.6 ± 0.9) and had better inter-slice alignment (1.4 ± 0.5 vs 1 ± 0). Average percentage difference between 2D and 3D cine SSFP volumetric data is shown in table 3, and Figure 2. Comparative flow analysis between 2D PC and 4D PC data revealed broad correlation (Figure 2, table 3) though the stroke volume, forward and backward flows through the aorta were not statistically different (p > 0.35; paired Student's t-test)
The free breathing first pass MRA, equilibrium MRA, 3D cine SSFP, and 3D single-phase SSFP exhibit significant clinical utility. We demonstrate the feasibility of performing an observer independent comprehensive CMR in CHD utilizing FB 3D acquisitions for morphology, function and flow within 30 minutes using a 5-channel phased-array coil. Better acquisition hardware (eg., 32 ch coil) will lead to superior image quality.
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