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Coronary Atherosclerosis T1-weighed Characterization with integrated anatomical reference (CATCH)
Journal of Cardiovascular Magnetic Resonance volume 18, Article number: O22 (2016)
The detection of high-risk coronary atherosclerotic lesions before severe plaque complications is the "holy grail" in cardiology. Recently T1-weighted (T1w) MRI with  or without  contrast enhancement (CE) has been used for characterizing coronary plaques showing promising prognostic value . However the drawbacks of current protocols based on conventional Cartesian acquisition and navigator gating hinder the clinical application of this technique: a) coverage is limited to proximal coronary segments; b) spatial resolution is low and often anisotropic; c) because normal tissue in T1w images is highly suppressed, a separate MRA acquisition is needed to provide anatomical reference. The purpose of this work is to develop a highly accelerated MR technique for coronary plaque characterization with 1) whole-heart coverage, 2) fine isotropic spatial resolution, and 3) simultaneously acquired bright-blood anatomical reference.
CATCH consists of ECG-gated, inversion recovery (IR) prepared spoiled gradient echo sequence with golden angle 3D radial trajectory to acquire dark-blood T1w images and bright-blood reference images in an interleaved fashion (Fig. 1). Retrospective motion correction with 100% respiratory gating efficiency was performed as described previously . Healthy volunteers (n = 12) and CAD patients with stable and unstable angina (n = 26) were scanned on a 3T scanner (Siemens Magnetom Trio) before and after CE. Scan parameters: whole-heart 3D slab with FOV = 3303 mm3; spatial resolution = 1.13 mm3; TR/TE = 4.6/2.3 ms; number of radial projections = 8500; scan time = ~10 minutes depending on heart rate. After completing MRI, 21 CAD patients further underwent interventional X-ray angiography (XA) and intracoronary optical coherence tomography (OCT) for coronary plaque evaluation. OCT images were graded for high-risk coronary plaque features (lipid-richness, macrophages, microvessels, cholesterol crystals) by two experienced cardiologists without the knowledge of MR results.
All 38 subjects successful completed the pre-CE exams. All 12 healthy volunteers and 23 eligible patients also completed the post-CE exams. None of the healthy subjects showed coronary hyper-intensive plaques (CHIPs) in either pre-CE or post-CE T1w MRI. In total 3 patients showed CHIPs on pre-CE exams and 4 patients showed CHIPs on post-CE exams, respectively. Fig. 2A and Fig. 2B are two representative patient cases with a pre-CE CHIP and a post-CE CHIP, respectively, with corresponding imaging evidences from other modalities. Fig. 2C is the lesion-based statistics showing elevated plaque hyper-intensity in the advanced lesions as classified by OCT.
The proposed MR technique of accelerated T1w whole heart coronary plaque characterization with simultaneously acquired anatomical reference was feasible. Coronary plaque hyper-intensity showed positive association with certain high-risk plaque features on OCT.
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Xie, Y., Pang, J., Kim, Y.J. et al. Coronary Atherosclerosis T1-weighed Characterization with integrated anatomical reference (CATCH). J Cardiovasc Magn Reson 18, O22 (2016). https://doi.org/10.1186/1532-429X-18-S1-O22
- Optical Coherence Tomography
- Coronary Plaque
- Optical Coherence Tomography Image
- Anatomical Reference
- Plaque Feature