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- Open Access
Post-contrast T1-mapping provides a novel approach to optimal myocardial nulling for late gadolinium enhancement imaging: a quantitative prescription for the correct TI without the guesswork
© Ferreira et al. 2016
- Published: 27 January 2016
- Late Gadolinium Enhancement
- Late Gadolinium Enhancement Imaging
- Intravenous Gadolinium
- Gadoterate Meglumine
- Pathologic Myocardium
Late gadolinium enhancement (LGE) is a well-established technique that generates excellent contrast between normal and pathologic myocardium. Selecting the correct inversion time (TI) for nulling normal myocardium is essential for good quality images and accurate diagnosis. The Look-Locker (LL) TI scout is commonly used for TI estimation but is subjective and requires a long breath-hold (20 heartbeats). T1-mapping is a quantitative method that can provide a direct numeric TI prescription in a shorter breath-hold but has not been tested in practice.
CMR: 39 subjects (19 men, 51 ± 16 yrs) with a variety of cardiac conditions underwent CMR at 1.5T (Siemens Avanto MR system; Syngo VB17A). All received intravenous gadolinium contrast (Gadoterate meglumine, Dotarem; 0.10 mmol/kg). Imaging included the LL TI scout followed immediately by post-contrast T1-mapping (ShMOLLI; WIP561; 9 heartbeats) at a mid-ventricular short-axis slice, and LGE (PSIR) imaging using conventional TI selection based on visual assessment of the TI scout according to radiographer experience.
Image processing: matching regions of interest (ROIs) were prescribed on LL TI scout, post-contrast T1-maps and LGE images in an area of the LV without obvious abnormality. LL TI was calculated by linear interpolation of sign reconstructed from the 5-6 lowest SI measurements, while T1-map TI was calculated as TI = 0.69 × T1 from post-contrast T1-maps. We also measured the average SI of the ROI on LGE images to assess for adequate nulling (SI=0) of the myocardium.
Post-contrast T1-mapping is an easy way to provide a direct numeric TI for optimal myocardial nulling in a single short breath-hold, reducing operator error and improving robustness for LGE imaging.
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