- Poster presentation
- Open Access
New automatic algorithm for segmentation of myocardial scar in both inversion recovery and phase sensitive inversion recovery late gadolinium enhancement: validation against TTC and in multi-center, multi-vendor patient data
© Tufvesson et al. 2016
- Published: 27 January 2016
- Percutaneous Coronary Intervention
- Infarct Size
- Late Gadolinium Enhancement
- Inversion Recovery
- Partial Volume Effect
Late gadolinium enhancement (LGE) using magnitude inversion recovery (IR) or phase sensitive inversion recovery (PSIR) has become clinical standard for assessment of myocardial scar. However, there is no clinical standard for quantification of myocardial scar even though multiple methods have been proposed . Simple thresholds have yielded varying results and advanced algorithms have only been validated in single center studies. The weighted algorithm implemented by Heiberg et al.  has recently been used by a core lab in two multi-center studies and accounts for both partial volume effects and microvascular obstruction. However, the weighted algorithm was validated in a single center study and PSIR images were not accounted for. Therefore, the aim of this study was to develop an automatic algorithm that accounts for both IR and PSIR LGE images and validate the new algorithm against TTC and multi-center, multi-vendor patient data.
The new automatic algorithm was implemented using an intensity threshold defined by expectation maximization (EM) followed by the weighted approach to take partial volume effects into account and improved detection of microvascular obstruction.
The new automatic algorithm and reference delineation in IR and PSIR images was validated against TTC in six pigs with myocardial infarction imaged after seven days of reperfusion. The new automatic algorithm was also validated against reference delineation in 127 patients from the multi-center, multi-vendor studies CHILL-MI and MITOCARE in IR (n = 75) and PSIR (n = 52) images. All patients underwent CMR imaging within 2-6 days following first time ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI). Reference delineation was performed by a core lab using the original weighted algorithm followed by manual corrections and consensus reading. Analysis was performed using bias (mean ± standard deviation) and linear regression analysis (correlation coefficient). Results are expressed as percent left ventricular mass %LVM.
Validation against TTC in six pigs with chronic myocardial infarction
Bias to TTC [%LVM]
Bias to TTC [%LVM]
New automatic algorithm
-1 ± 1
-2 ± 2
-1 ± 1
0 ± 0
The new automatic algorithm was validated against TTC and in multi-center, multi-vendor patient data with a low bias for both IR and PSIR images. Results show that the new algorithm performs equally well in images acquired with both sequences. The new automatic algorithm can be used as an improved tool for segmentation of myocardial scar in IR and PSIR images.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.