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Clinical Evaluation of 3D High Resolution Late Enhancement using Image-Based Navigation
Journal of Cardiovascular Magnetic Resonance volume 18, Article number: P310 (2016)
Objective
To prospectively assess the diagnostic performance of high resolution image-navigated 3-dimensional late gadolinium enhancement (iNAV-3D LGE) magnetic resonance imaging (CMR) for the detection of myocardial necrosis in a routine clinical setting.
Background
iNAV-3D LGE is a novel CMR technique which allows for direct respiratory motion correction of the heart. However, its performance in real-life clinical scenarios has not yet been established.
Methods
23 consecutive patients referred for CMR examination including scar imaging were prospectively enrolled. Gadolinium enhanced (0.20 mmol/kg Gd-DTPA) navigated high resolution (2 mm3 isotropic) 3D T1-weighted gradient-echo inversion recovery sequence using image-based navigation in comparison with a conventional two-dimensional (2D LGE) sequence were performed in random order by using a 1.5-T clinical MR imaging system. Images were assessed qualitatively with regard to the detection of global and segmental LGE and transmurality. Additional subjective image quality assessement including image quality, mean LGE signal intensity and LGE-myocardial/ blood pool sharpness on a 4-point scale was performed.
Results
Interpretable images were obtained in all 2D-LGE and in 22/ 23 iNAV-3D LGE exams, resulting in a total of 22 complete sequence datasets and 352 segments. LGE was detected in 5 patients with ischemic pattern, in 8 with non-ischaemic pattern, while it was absent in 9 cases. (Figure 1) There were no significant differences between 2D and 3D data sets with regard to global and segmental LGE detection (p, 0.13 and p, 0.28, respectively) and transmural extension (p, 0.84). Agreement regarding image quality was good, but 2D LGE presented higher LGE mean signal intensity. (Table 1) The average acquisition time for iNav-3D was from 4-6 minutes. Results were similar indepentently of the order in which the sequences were performed.
Conclusions
In this study, imaging performance and quality scores of iNAV-3D LGE images were comparable to those of 2D LGE in a prospective clinical setting. iNAV-3D LGE may potentially offer a reliable alternative for high quality scar imaging.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Bratis, K., Grigoratos, C., Henningsson, M. et al. Clinical Evaluation of 3D High Resolution Late Enhancement using Image-Based Navigation. J Cardiovasc Magn Reson 18 (Suppl 1), P310 (2016). https://doi.org/10.1186/1532-429X-18-S1-P310
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DOI: https://doi.org/10.1186/1532-429X-18-S1-P310
Keywords
- Late Gadolinium Enhancement
- Subjective Image Quality
- Inversion Recovery Sequence
- High Resolution Late
- Image Quality Assessement