Reliable detection of subendocardial ischemia by high-resolution end-systolic first-pass perfusion imaging in the absence of obstructive coronary disease
© Sharif et al. 2016
Published: 27 January 2016
Among the patients without known disease undergoing invasive angiography, nearly 40% do not have coronary artery disease (CAD) . A possible underlying etiology for such patients is ischemic heart disease associated with coronary microvascular dysfunction (CMD). Despite intense interest and recent advancements, reliable diagnosis of CMD on the basis of first-pass perfusion (FPP) cardiac MRI is an ongoing challenge. We hypothesized that high-resolution systolic FPP imaging can detect diffuse vasodilator-induced subendocardial defects and transmural perfusion gradients (TPGs) consistent with CMD in a swine model of diet-induced diabetes with no obstructive CAD. To this end, we optimized and tested a recently introduced high-resolution FPP method capable of imaging all myocardial slices at the end-systolic phase.
Yucatan mini-pigs (n = 8 males) were fed either a high-fat high-sugar diet (n = 4 "HFHS" group) or a normal chow diet (n = 4 "control" group) for 20 weeks. Compared to controls, the HFHS pigs were obese (68 ± 8 kg vs 45 ± 7), and had abnormally elevated fasting glucose (177 ± 19 mg/dL vs 94 ± 12) and insulin levels, indicating early-stage type-2 diabetes and expected to have CMD based on previous studies . Obstructive CAD was ruled out in all pigs using invasive angiography on the day of the MRI study, consistent with their normal serum lipid levels. There was no difference between baseline arterial systolic blood pressure between the two groups, suggesting absence of hypertension in the HFHS group. Adenosine stress/rest FPP data was acquired using a recently introduced T1-weighted steady-state ungated FLASH sequence  with optimized slice-interleaved radial sampling (acquired in-plane resolution: 1.2 × 1.2 mm2). Retrospective end-systolic self-gating was performed automatically (temporal resolution: 32 ms) and compressed sensing combined with apodization was used to generate dark-rim-minimized images. TPG analysis was performed according to the established approach .
We demonstrated that subendocardial ischemia and stress-induced TPGs can be visually detected in the absence of obstructive CAD using an optimized FPP approach. The combination of high isotropic in-plane resolution, end-systolic imaging of all slices, and dark-rim-minimized reconstruction enables reliable detection of subendocardial defects. Our results suggest that this methodology may be a promising approach for accurate diagnosis of CMD in clinical settings.
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